KRAS蛋白蕴含4个结构域。KRAS蛋白由6条β-折叠链和5条-螺旋结构组成，形成两个重要结构域：G结构域和C端结构域。

KRAS protein contains 4 domains.KRAS protein is made up of 6 beta-strands and 5 alpha-helicies, which form two major domains: G-domain and C-terminal.

KRAS的G结构域由残基1-166组成，蕴含GTP结合口袋，该区域对于下游效应物和GTPase激活蛋白之间的相互之间作用至关重要。

The G-domain  of KRAS, comprised of residues 1-166, includes the GTP-binding pocket, a region within which is essential for the interactions between the putative downstream effectors and GTPase-activating proteins.

G结构域是高度守旧的，蕴含掌管GTP-GTP互换的switch Ⅰ和switch Ⅱ区域。

The G domain is highly conserved and contains switch Ⅰ and switch Ⅱ loops, which are responsible for GDP-GTP exchange.

C端是一个蕴含CAAX基序的高变区，疏导翻译后建饰并决定细胞膜锚定，该区域在RAS蛋白的生物活性调控中起着重要作用。/p>

The C-terminal, a hypervariable region including the CAAX motif, guides posttranslational modifications and determines plasma membrane anchoring. This region plays an important role in the regulation of the biological activity of RAS protein.

KRAS新药研发平台

什么是KRAS?

6008集团助力信诺维抗肿瘤1类新药XNW14010（幼分子KRAS G12C蛋白共价结合抑造剂）获批临床